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Pharmacovigilance and signal detection FAERS semaglutide disproportionality (broad): A FAERS-based disproportionality analysis of semaglutide reports through mid-2023 identified multiple unexpected adverse event signals and explicitly notes that some signals were not mentioned in the drug insert, including polycystic ovaries. The analysis highlights typical spontaneous-reporting limitations (missing age, outcome data)

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Supporting this, a large population-based review by Eberle et al

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[DOI] [PubMed] [Google Scholar] 27.Orforglipron, an oral non-peptide glucagon-like peptide-1 receptor agonist, improves markers of -cell function and insulin sensitivity in type 2 diabetes