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Martin-Rodriguez E, Guillen-Grima F, Marti A, Brugos-Larumbe A

If 500 mcg EOD is not producing noticeable effects after a reasonable trial period: Increase to 750 mcg EOD (22.5 units) If still insufficient, increase to 1 mg EOD (30 units) Wait 5 to 7 days between any dose changes to accurately assess your response before adjusting further Do not rush this phase

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(Watch for more details on this.) Physicians must also submit a prescription and prior authorization request to the central processor when required