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Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
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DOI: 10.1186/s12970-017-0177-8
16 , 17 , 18 Furthermore, improvements in glycaemic control have been observed in both randomised controlled trials and retrospective observational studies where patients were switched from one GLP1RA to another

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Conversely, the randomized, placebo-controlled, phase 3 study by Elkind-Hirsch et al

Digenio A, Pham NC, Watts LM et al (2018) Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1BRx Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes
