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Scenario 2: Recurrent UTIs after starting semaglutide You have had two or more UTIs since beginning semaglutide, and you rarely had them before

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Proper medication titration following the FDA-approved dosing schedule allows the body to adapt gradually to the medication's effects

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

Because the primary estimand was the total effect of treatment initiation, adjustment for these post-baseline variables could introduce bias