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Description
Each n represents a biological replicate from 7 ( A and B ), 10 ( C and D ), and 2 ( E and F ) independent cohorts of sex- and age-matched animals

Effects of GLP-1 and GIP receptor agonists include: Stimulating insulin secretion in response to food (glucose-dependent) Reducing inappropriate glucagon release, lowering hepatic glucose output (GLP-1 enhances the sensitivity of alpha cells to glucose , resulting in more glucose-appropriate glucagon secretion) When blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited

Sukumaran and colleagues treated Zucker lean and obese rates with either vehicle or the GLP-1 agonist liraglutide (LIRA) for 8 weeks [66]

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First, an amino acid substitution stops DPP-4 from destroying GLP-1
