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It increases insulin secretion when blood sugar rises

162 Pancreatic polypeptide is known to reduce pancreatic secretion to slow digestion but the effects on the rest of the GIT in humans are not currently clear

A 2023 study published in JCI Insight found that GLP-1 agonists reduced alcohol intake in rodents by modulating dopamine signaling in the brain's reward circuits

Clinical trials and FDA approvals were based on weekly dosing, so there is limited evidence based on extended intervals

There is no scientific evidence supporting the effectiveness of these supplements for weight loss or blood sugar management." Kumar adds that GLP-1 supplements are "largely a marketing ploy to capitalize on the current cultural craze around weight loss medications." If they do have an effect, it's likely mild and "not effective enough to treat overweight and obesity," she explains
