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By week 23, as your body adapts to lower calorie intake, you may see more measurable weight changes on the scale

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But the second person is eating more food, getting more protein, getting more micronutrients, and preserving more muscle

The core machinery of this axis is the IP3R-GRP75-VDAC1 tripartite complex, where GRP75 (Szabadkai et al., 2006) acts as a linker protein that physically bridges the IP3R on the ER (Bartok et al., 2019) to the VDAC1 channel on the mitochondria (Rapizzi et al., 2002), funneling ions directly into the mitochondrial matrix (Szabadkai et al., 2006)