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The FoxO transcription factor family plays a prominent role in muscle physiological regulation, especially the FoxO3a subtype, which plays a key role in muscle autophagy, metabolic regulation, and sarcopenia occurrence by regulating the expression of autophagy-related genes (such as LC3 and BNIP3) [48]

Research models have explored GLP-1 C for its ability to support insulin sensitivity, reduce food intake, and influence metabolic pathways related to obesity and type 2 diabetes

These clinical observations were supported by preclinical experiments, in which DPP-4 inhibition had no effect on alcohol intake in rodents

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