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In laboratory settings, researchers examine how Semaglutide mimics the action of native GLP-1 by binding to GLP-1 receptors, resulting in enhanced insulin secretion, suppressed glucagon release, slowed gastric emptying, and central regulation of appetite

Potential Side Effects Nausea and vomiting Diarrhea or constipation Abdominal pain and bloating Loss of appetite and altered taste Injection-site reactions (if applicable) Headache and fatigue Most side effects are mild and drop off after a few weeks as the body adjusts

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These drugs show a reduced risk of stroke and as much as a 15% total body weight loss in adults

10.1016/j.cgh.2019.03.047 90

The mechanisms by which GLP-1RAs and SGLT2is exert their cardiovascular and renal benefits (Fig