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Inconsistent dosing can produce erratic blood levels that are worse than the peaks and troughs of standard weekly dosing

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These medications dont cause a dangerous withdrawal syndrome, and stopping isnt like abruptly quitting a blood pressure medication

Brain-derived GLP-1 is synthesized in a subset of neurons in the NTS that project to GLP-1Rexpressing regions in the hindbrain and hypothalamus, including the paraventricular nucleus (PVN), dorsal medial nucleus of the hypothalamus, and arcuate nucleus (ARC), as well as the NTS itself

Mazdutide (Innovent Biologics) is another dual GLP-1/glucagon agonist showing promising results in Chinese patient populations