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Another plausible mechanistic explanation for a diminished incretin effect is the TCF7L2 -dependent repression of GLP-1R and GIPR expression on the -cells [569]

The review will adhere to the methodology outlined in the Joanna Briggs Institute Reviewers Manual [2], and will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) [8]

Jeffrey Egler, Chief Medical Officer at Noom

Comparative effectiveness of sodiumglucose cotransporter 2 inhibitors vs sulfonylureas in patients with type 2 diabetes

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Chronic knee pain limits physical activity, which promotes weight gain and worsens metabolic control, which drives further systemic inflammation, which accelerates joint damage, which increases pain further