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A meta-analysis of 45 randomized controlled trials observed a trend toward increased risk of thyroid dysfunction in patients treated with GLP-1 receptor agonists, although the findings did not reach statistical significance
Although AICAR increased expression of Ppar in an AMPK-dependent manner in INS-1 832/3 cells, the inductive effects of AICAR on Ppar were independent of PPAR- activity (Fig

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