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In terms of evidence, insights usually come from three places: randomized trials that catalogue adverse events, real-world observational cohorts that follow patients over time, and pharmacovigilance databases that gather spontaneous reports

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The first time we saw this was during the liraglutide trials where blood pressure reduction occurred within 2 weeks of initiation of therapy, which was before any meaningful weight benefit was demonstrated suggesting that weight loss is not the driver of the blood pressure benefits

However, the FDA, Eli Lilly, and Novo Nordisk are all cracking down on companies continuing to offer compounded GLP-1s under false pretenses

They can contain hair, skin, even teeth