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The active ingredient in Zepbound is tirzepatide, which acts on both GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) hormone receptors to reduce appetite, leading to weight loss

doi:10.1002/oby.24360

doi: 10.1001/jamainternmed.2019.4802
Post-meal pharmacodynamic profile of AVE0010, a once-daily GLP-1 receptor agonist, in patients with type 2 diabetes inadequately controlled on metformin [abstract 131]

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