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Thyroid changes: both drug classes carry a theoretical risk based on preclinical (animal) data

The American Diabetes Association recommends discussing potential gastrointestinal side effects with patients before starting GLP-1 receptor agonist therapy to set appropriate expectations and develop management strategies

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Experts say patients who are taking semaglutide or considering treatment should discuss the risks and benefits with their doctors, especially those who have other known optic nerve problems such as glaucoma or preexisting visual loss