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However, while GLP-1 RAs did not exhibit an increased risk of acute pancreatitis, DPP-4 inhibitors demonstrated a notable risk elevation (rate ratio, 1.75) [53]

Understanding how each medication functions is essential for recognising potential interactions and optimising treatment outcomes

When both medications act on your digestive system simultaneously, nausea, bloating, and reflux risk increases, especially during the first weeks of semaglutide dose adjustment