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One of the key reasons Retatrutide can be given as a once-weekly injection is its half-life the time it takes for the concentration of the drug in the body to be reduced by 50%

In an email, Genna Hymowitz, director of metabolic and bariatric psychology and a clinical associate professor at Stony Brook Medicine, said more research was needed "before we prescribe GLP-1s to people who are not overweight, and we need to better understand the long-term risks of GLP-1s

This includes heart disease, heart attacks, stroke, and bowel cancer

2022 Feb;179(4):625-641

It is a receptor agonist and should not replace insulin therapy in individuals who require it

So we have that first approved drug