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Description
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A brief review was conducted to explore current evidence on the interaction between GLP-1RAs and gut microbiotatermed the pharmaco-gut axis. Literature was examined to understand how specific microbial populations affect drug efficacy and insulin sensitivity

Additional medications such as sulfonylureas, dipeptidyl-peptidase-4 inhibitors, thiazolidinediones, and glucagon-like peptide-1 receptor agonists should be added as needed in a patient-centered fashion

GLP-1 RAs showed several adverse gastrointestinal effects in non-diabetic patients with overweight or obesity
Through its unique mechanism of action as a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, as well as its impressive results in clinical trials, tirzepatide has the potential to completely transform the current approach to treating obesity

These drugs are changing more than our body weight.
