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Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats

[...] The robust inhibitory action of desipramine on the tyramine pressor response was expected based on prior reports from ours, and several other laboratories

The successful development of glucagon-like peptide-1 (GLP-1) receptor agonists, followed by the synergistic combined effect of glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists achieved remarkable weight loss and glycemic control in those with the diseases of obesity and type 2 diabetes

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doi: 10.1021/acs.jmedchem.5b00726 [DOI] [PubMed] [Google Scholar] 71.Deacon CF, Knudsen LB, Madsen K, Wiberg FC, Jacobsen O, Holst JJ

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