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Baseline electrocardiography may be considered in patients with known arrhythmias or significant cardiac history

Key contraindications include pregnancy and breastfeeding, with caution advised in those with thyroid disease, pancreatitis history, or severe gastrointestinal disease

Trulicity is officially approved for the treatment of Type 2 diabetes in combination with diet and exercise and for the reduction of cardiovascular mortality

Understanding Semaglutide's Timeline for Weight Loss Results Semaglutide begins affecting appetite within the first few doses, typically producing appetite reduction and early weight changes by week 2 to 3

Del Prato S, Kang J, Trautmann ME, Stewart J, Sorli CH, Derwahl M, et al

The SELECT trial, which included patients with CV disease and overweight or obesity (many also had increased risk for diabetes), showed a reduction in major adverse CV events (defined as CV death, nonfatal heart attack, and nonfatal stroke) of 20% with weekly subcutaneous semaglutide 2.4 mg