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Participants 43365 adults (18 years) with type 2 diabetes who used a GLP-1 receptor agonist or SGLT-2 inhibitor within 30 days before upper gastrointestinal endoscopy

The observations that GLP-1 receptor agonists exert anti-inflammatory actions in preclinical studies, taken together with case reports linking improvements in psoriasis with GLP-1 receptor agonist therapy, illustrates the emerging clinical implications of non-classical anti-inflammatory actions of incretin-based therapeutics.

Amylyx updates investors on its rare disease pipeline, including avexitides Phase 3 LUCIDITY trial, AMX0035 in Wolfram syndrome, AMX0114 in ALS, and a $317M cash position with runway into 2028 through potential avexitide approval and launch in 2027.

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Adapting to Oral GLP-1 Concerns The regulatory themes highlighted in the compounded spaceaccuracy in claims, proper oversight, and clear labelingare equally relevant to oral GLP1 options

At study entry, 38% of the patients were taking sodium glucose cotransporter 2 (SGLT2) inhibitors or glucagon-like peptide-1 receptor agonists (GLP-1 RAs), medications for diabetes that have been shown to have beneficial effects on heart disease, including reducing heart failure, heart attacks and strokes