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A dominant-negative human G s (DNG s ) with 8 mutations (S54N, G226A, E268A, N271K, K274D, R280K, T284D, and I285T) was generated as previously described to limit G protein dissociation 51

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[DOI] [PMC free article] [PubMed] [Google Scholar] 386.Li, J

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Phase I and II clinical trials corroborate these findings, showing dose-dependent weight loss, reductions in Glycated Hemoglobin (HbA1c) levels, and improvements in liver steatosis and diabetic kidney disease

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