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The additional GIP activity enhances insulinotropic effects and may amplify weight loss via both central and peripheral pathways not fully replicated by GLP-1 agonism alone 5

A few of the most common causes include: Clinicians prescribing medications have a responsibility to the patient whose life they are putting in their hands
The single-dose vials are priced at a 50% or greater discount compared to the list price of all other incretin (GLP-1) medicines for obesity

Cecot J, Zarzecki K, Mandryk M, Parfianowicz A, Plizga J, Guszczyk A, et al

Both require combination with lifestyle modifications for optimal results

Here, we primarily discuss GLP-1RAs that are currently approved and under consideration for MASLD, along with some co-agonist strategies showing promising results
