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Suppression of angiotensin II-activated NOX4/NADPH oxidase and mitochondrial dysfunction by preserving glucagon-like peptide-1 attenuates myocardial fibrosis and hypertension

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55 Likewise, data on mean BMI among HFrEF participants may not reflect the presence and severity of obesity as a target for the potential effectiveness of GLP-1 RAs

95% CI, 19.5 to 0.1 mmHg

In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]

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