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This confirms a causative role of elevated gut-derived 5-HT as a driver of metabolic dysfunction

placebo treatment) for nausea and vomiting were similar for various compounds/preparations of GLP-1RAbased medications, while intended effect sizes (glycemic control and body weight reduction) varied widely (Table 2)

However, conversely, these findings may suggest that in non-obese patients, the BP-lowering effect of SGLT2i is sufficient even as a monotherapy

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