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The sub-classification into Specified or Non-Specified are important only in the sanctioning process

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Patients were followed from 1 year after cohort entry until a diagnosis of incident adverse CVEs, switch to a comparator drug, any cause of death or the end of the study (30 September 2022), whichever occurred first

The inhibitory effect of GLP-1R analogs on reward behaviors is blunted in mice with CNS-specific deletion of GLP-1R [748]

By acting on both the homeostatic (hunger-driven) and hedonic (pleasure-driven) aspects of eating, GLP-1 effectively recalibrates the brains perception of food