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Reduction in TNF alpha and oxidative stress by liraglutide: impact on ketamine-induced cognitive dysfunction and hyperlocomotion in rats

doi: 10.1056/NEJMoa0806359 [DOI] [PubMed] [Google Scholar] 5

The latest diabetic retinopathy preferred practice guidelines from the American Academy of Ophthalmology indicate that the rising use of GLP-1RAs may lead to quick glycemic control and severe hypoglycemia and has been reported to cause higher rates of retinopathy complications, especially in patients with early-stage DR (Lim et al., 2025)

Given this close association, a substantial number of obese individuals likely suffer from undiagnosed OSA, underscoring the need for proactive screening in obesity care

In addition, because the studies participants had severe hyperglycaemia, metformins glucose-lowering effect may have also been related to changes in peripheral insulin sensitivity, but this was not measured in those studies

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