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As shown in Figure 5, nevertheless, the two positively charged side chains of Arg123 and Arg127 remain as close to each other as only a little over 3.0 , leading to an electrostatic repulsion between the two residues, which is energetically unfavorable

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In the phase 2 clinical trial of retatrutide for adults with obesity (without type 2 diabetes), a clear dose-dependent response was observed between the administered dose and weight loss outcomes