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There appear to be considerable species-specificity in terms of anatomical localization of GLP-1 production as summarized in Figure 1

Authors contributions JFAM: Writing - original draft,Visualization,Writing - review & editing

Finnerup, Sandra Sif Gylfadottir Journal of the Peripheral Nervous System.2023

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Novo Nordisks Long March Pramlintide, as the first-generation amylin analog, was groundbreaking but had shortcomingsmost notably, a short plasma half-life of only 3050 minutes, requiring three daily injections