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Research demonstrates that omega-3 supplementation can reduce DPP-4 activity, though the mechanism appears to be through anti-inflammatory pathways rather than direct enzyme inhibition
Cardioprotective Mechanisms of Exenatide in Isoprenaline-induced Myocardial Infarction: Novel Effects on Myocardial -Estrogen Receptor Expression and IGF-1/IGF-2 System
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Second, the cognate receptor must be known or plausibly identifiable, enabling mechanistic interrogation and rational drug design
