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Improvement of PLGA loading and release of curcumin by supercritical technology

Results obtained in preclinical models indicate that GLP-1 improves endothelial dysfunction, prevents vascular remodeling, and activates the endothelial nitric oxide synthase-nitric oxide-cGMP pathway

Its trial-derived safety profile to date is dominated by the expected GLP-1 gastrointestinal effects, generally mild to moderate and worst during dose escalation, but long-term and real-world safety the kind that only emerges after wide, prolonged use is by definition not yet available

10.1152/ajpheart.00885.2010

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There is no scientific evidence supporting the effectiveness of these supplements for weight loss or blood sugar management." Kumar adds that GLP-1 supplements are "largely a marketing ploy to capitalize on the current cultural craze around weight loss medications." If they do have an effect, it's likely mild and "not effective enough to treat overweight and obesity," she explains