metformin vs glp-1 for weight loss Do You Still Need If You Take a Diabetes? Semaglutide vs. Metformin vs. Tirzepatide:

GLP-1 might also affect kidney function via its cardiovascular effects

Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus

This is sometimes called a whoosh effect, and while the mechanism is debated, the pattern is remarkably consistent across thousands of GLP-1 users

doi: 10.1016/0014-5793(72)80418-6

References Bodnaruc, A.M., Prudhomme, D., Blanchet, R

The GIP component is hypothesized to provide an additional mechanism to buffer against the hyperglycemic effects of glucagon [940], thus permitting triple agonists of higher potency at the glucagon receptor that in theory could drive more body weight loss