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The common PD animal models involve the use of neurotoxins such as MPTP (Dovero et al., 2016), 6-OHDA (Sauer and Oertel, 1994), and pesticides/herbicides including rotenone, paraquat, and maneb (Domico et al., 2006
A growing literature (2021-2024) has revisited the 5-HT2B hypothesis in light of modern receptor pharmacology and population pharmacovigilance signals, urging cautious long-term monitoring rather than wholesale exclusion of SSRI classes [33-35]
