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However, the changes in AST and ALT between the intervention and control groups were not statistically significant [39]

Compared to those receiving neither medication, all-cause mortality was significantly lower among patients treated with SGLT2-I only (HR 0.28, 95% CI 0.270.29), GLP-1RA only (HR 0.39, 95% CI 0.370.40) and both agents (HR 0.17, 95% CI 0.160.18)

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Recently, both the receptors have shown to heteromerize in vitro , eliciting synergistic signaling and -arrestin-2 recruitment (300)

These differences underscore the difficulty in defining HFimpEF, complicating efforts to standardize diagnosis, assess prognosis, and guide therapy across different healthcare settings

The clearest contraindications in the FDA labeling are a personal or family history of medullary thyroid carcinoma (MTC), the genetic condition MEN 2, and a known serious allergic reaction to the specific drug