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Comparative effects of alive and pasteurized Akkermansia muciniphila on normal diet-fed mice

Interestingly, studies examining placental passage of exenatide and liraglutide in human cases suggest minimal to no fetal exposure shortly after administration, indicating that maternal metabolic effects, rather than direct fetal exposure, may contribute to adverse outcomes

The SURMOUNT-1 DXA substudy found that tirzepatide produced a 33.9% reduction in fat mass and a 10.9% reduction in lean mass over 72 weeks, with approximately 75% of total weight lost coming from fat and 25% from lean mass

This contrasts with case reports of acute pancreatitis with the first approved GLP-1RA, exenatide b.i.d

Unlike many other glucose-lowering drugs, GLP-1 receptor agonists dont come with a relative contraindication for renal impairment
