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If recurrent genital thrush persists, review any concomitant SGLT2 inhibitor therapy, as these medications (unlike GLP-1 receptor agonists) are associated with increased risk of genital mycotic infections

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That third mechanism, glucagon receptor activity, is the reason it has attracted so much attention, and it is also the reason it requires more careful clinical oversight

The Sleepy Side Effect of GLP-1s: Managing Fatigue from Ozempic or Zepbound Jennifer Hardy Nov 30, 2025 7 min read Fatigue is one of the most underrated GLP-1 side effects

PlexusDx explains practical steps to take if this happens to you

Each option provides a safe, effective path to long-term success under medical supervision