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Preclinical and preliminary clinical evidence of semaglutides potential beneficial effects on various substance use disorders led us to evaluate if it pertained to CUD

The SURMOUNT trials in patients without diabetes showed even greater weight loss, with the 15 mg dose producing an average loss of 20.9 percent of body weight at 72 weeks compared to 14.9 percent for semaglutide in similar populations

For people comparing metabolic research areas, related reading categories include weight-management articles, type 2 diabetes articles, and broader diabetes articles

Lilly submitted an NDA in late 2025

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Chen J, Mei A, Wei Y, et al

Compounded semaglutide is often used as a weight loss medication