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The concern about blood clots may stem from confusion with other weight loss interventions or from the fact that obesity itself is a significant risk factor for venous thromboembolism

Other Potential Benefits A challenge with berberine is its low bioavailability

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More research is needed to understand the effect of other agonists, as cancer research is lacking

While studies on initial combination therapy have not yet directly demonstrated a reduction in long-term complications, the well-established benefits of tight glycemic control suggest that early combination therapy may contribute to lower complication rates in the future