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Clinical considerations : -Noncirrhotic MASH: There may be risks to the mother and fetus related to MASH with advanced liver fibrosis (e.g., increased risks of gestational diabetes, hypertensive complications, preterm birth, postpartum hemorrhage)

These include: Research and Nooms internal data indicate that combining GLP-1s with behavior-change support yields better, more durable outcomes than medication alone

In our review, we summarize evidence from randomized clinical trials and meta-analyses showing that ten approved and emerging obesity medications can improve a remarkably broad range of obesity-related conditions, including: Liver disease (MASLD and MASH) Chronic kidney disease PCOS (now increasingly referred to as PMOS, polyendocrine metabolic-ovarian syndrome) Obstructive sleep apnoea Osteoarthritis and physical functioning Cardiovascular disease Prediabetes and type 2 diabetes Importantly, many of these benefits are related to weight loss itself

In addition to helping with weight loss, GLP-1s have been shown to support better overall wellness, including improved blood sugar control, lower risk of heart and kidney disease and relief from joint or sleep-related issues caused by excess weight