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We employ variants of the peptides GLP-1 and exendin-4 to explore the interplay between helical propensity near the agonist N-terminus and the ability to bind to and activate the receptor
GLP-1s have much more long term safety data although have the undesirable side effect of sarcopenia (loss of muscle mass)
The FDA approved the drug semaglutide for those suffering from obesity, diabetes, and other weight-related illnesses
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