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Description
To view digital features for this article go to Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are successfully used in the treatment of type 2 diabetes mellitus, improving glycaemic control with low risk of hypoglycaemia and inducing weight loss [1, 2]
HN treatment decreased cytokine (tumor necrosis factor alpha, interleukin gamma [IFN-])-induced -cell apoptosis measured by caspase 3/7 activity, improved glucose tolerance measured by intraperitoneal glucose tolerance test (IPGTT), lowered the degree of insulitis, and delayed the onset of diabetes in female NOD mice [29]

While each patient relies on one pen to cover the four required monthly shots recommended by Novo Nordisk, the pharmacys limited stock means it can only accommodate a handful of diabetic patients each month

A liver biopsy can paint a clearer picture

Prescription GLP-1 drugs produce 724% body-weight loss in phase 3 trials

Type 2 diabetes May be filed simultaneously or shortly after, supported by the TRANSCEND-T2D program (TRANSCEND-T2D-1 reported March 19, 2026)
