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In other words, metformin isn't just a glucose-lowering drugit's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems

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The answer may be a little more complicated than you might think

Glucagon-like peptide-1 receptor agonists (GLP-1RA) have shown potent metabolic benefits in type 2 diabetes (T2D) and obesity, but their efficacy and safety in CS remain unexplored

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