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58 Thus weight loss, whether mediated by GLP-1 agonists or other means, may be effective in improving symptoms in individuals with obesity and knee OA, but may not change the progression of knee and hip OA in the same population

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Weight Regain Timeline and Metabolic Rebound Research published through 2025 indicates that patients who discontinue GLP-1 without lifestyle modification regain 2550% of lost weight within 12 months, with some regaining most or all weight within 1824 months

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