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Preclinical models, clinical trials and real-world observational studies strongly support the hypothesis that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors may confer neuroprotective benefits

These facts, together with increasing comorbidities in patients with IBD, imply that urgent, more complex, novel therapeutic strategies in the treatment are needed

The resulting tear or cut in the mucosal lining can expose the muscle around the anus known as the anal sphincter

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GLP-1 agonists do more than support weight lossemerging clinical evidence shows they can meaningfully reduce blood pressure in patients with hypertension

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