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Cardiovascular effects of GLP-1 RAs have been of great interest since the burden from cardiovascular diseases (CVD) has been unbearably increasing in a diabetic population worldwide, despite strict glycemic control and advanced therapeutic techniques to treat CVD

Systematic meta-analyses have established that sulfonylurea therapy shows no protective effect against prostate cancer development in patients with diabetes mellitus [102]

Two recent meta-analyses of eight cardiovascular outcome trials (CVOTs) and several other meta-analyses that included non-CVOT studies estimated the reduction in cardiovascular mortality varied between 12 and 15% (Zheng et al., 2018

Implications for Drug Testing Given the metabolic characteristics of semaglutide, it is highly unlikely that this medication would be detected in standard drug tests designed to identify controlled substances or their unique metabolites

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Retatrutide is an investigational peptide-based medicine currently under clinical evaluation for the treatment of obesity and type 2 diabetes mellitus