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A new Phase 2 trial at Johns Hopkins testing the GLP-1 drug pegsebrenatide in progressive MS may finally explain why adults on diabetes medications for a decade show measurably slower brain shrinkage

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It is also prescribed for long-term weight management in adults and adolescents aged 12 years and older with obesity, and in adults with overweight who have a weight-related health condition

Novo Nordisks Peter Johannsen, MD, highlighted the biological signals observed and acknowledged the clinical limitations: subgroup analyses did not reveal meaningful benefit, and any potential responder group would be very small

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Rybelsus, the oral semaglutide, has become a popular weight loss drug
