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Conclusion Modulation of GLP-1R affects CSF production, which suggests that GLP-1R-mediated signalling may have the potential to control ICP in pathological conditions with disturbed CSF homeostasis.

Understand the legal challenges and how pharmaceutical giants are responding

Zooming out, the obesity market is now clearly split across modalities: Novo Nordisk still anchors the peptide side with semaglutide, while oral small molecules are accelerating (orforglipron, elecoglipron and Roches Carmot deal)

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GLP-1 receptor agonists, including semaglutide and tirzepatide, have revolutionized the approach to weight loss