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2.5 Urine collection and UACR determination Before (910 weeks of age) and at the end of the study (1920 weeks of age), the first void spontaneous spot urine was obtained using an in-house urine multicollector for rodents (Patent U202131356 (ZBM reference U691ES00), Spanish Patents and Trades Office)

Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as one of the most transformative therapeutic classes in modern medicine

Side Effects Change in how much or how often you urinate, lower back or side pain, blood in your urine Unusual moods or behaviors, depression, thoughts of hurting yourself or others Blurred vision or any other change in vision Warnings Tell your doctor if you are breastfeeding, or if you have kidney disease, pancreas problems, diabetes, digestion problems (including gastroparesis), or a history of diabetic retinopathy or depression

By dampening inflammation and modulating microglial activity, GLP-1 RAs create a neuroprotective environment that supports neuronal survival [78]

Br J Pharmacol 166: 27-41, 2012

EAT is usually quantified non-invasively using transthoracic echocardiography, computed tomography, or cardiac magnetic resonance[4]