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Whilst these effects might appear complementary, the combined hormonal and metabolic signalling could produce effects that are difficult to monitor or predict without clinical oversight

Nat Metab 2(5):413431 Nestor JJ, Parkes D, Feigh M, Suschak JJ, Harris MS (2022) Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis

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In rats, liraglutide decreases food intake when directly injected into the ARC, LHA, or PVN while direct administration into the VMH decreases body weight without affecting food intake, but increases the expression of Ucp1 in the brown and inguinal white adipose tissue [666]

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This is significant for patients undergoing anesthesia for procedures, where aspiration risks are heightened by factors like a full stomach and reduced consciousness