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There is no established pharmacological mechanism by which GLP-1 receptor agonists would increase leptin synthesis from adipocytes

doi:10.1371/journal.pone.0122704 Commissioner O of the

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While this approach minimizes population stratification biases, it may limit the generalizability of our findings to other ancestral groups

Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype